Can mRNA vaccines change my genes?

No, mRNA from the COVID-19 vaccine never enters the nucleus of the cell and does not affect or interact with your DNA. mRNA are naturally occurring genetic molecules that instruct our cells how to create proteins that build, maintain, and repair things in the body. Minutes after our cells make the proteins, the body destroys the mRNA using a special enzyme.

mRNA in vaccines are designed to withstand the enzyme a little bit longer (a few days at most) so that our cells can create enough of a harmless protein that is unique to the virus. After our cells make copies of the virus’ protein, our immune system is triggered and recognizes that the protein should not be in our body. Our body then builds antibodies so that it remembers how to fight the virus if we are infected in the future.

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